A clinico-electrophysiologic diagnosis does not eliminate the need to confirm by serological (HMGCR-IgG and SRP-IgG)
and muscle biopsy testing patients suspected of having IMNM.
Finger flexor greater than extensor weaknesses favors non-IMNM etiologies, including sIBM, GNE myopathies.
Clinical variables IMNM vs diverse other myopathiesa (univariate analysis)
Dermatomyositis (DM), sporadic inclusion body myositis (sIBM), polymyositis (PM), mitochondrial myopathies (MtM),
limb girdle muscular dystrophies (LGMD), myotonic muscular dystrophy (MMD), nonspecific inflammatory myopathies
Values were significant p < 0.05
Odds ratios < 1 are protective against IMNM = immune mediated necrotizing myopathy.
Triplett J.D; Shelly S; Livne G; Klein C.J. Diagnostic modeling and therapeutic monitoring of
immune-mediated necrotizing myopathy: Role of electrical myotonia. Brain
||Odds Ratio favoring IMNMc
||Lower 95% Confidence Limit
||Upper 95% Confidence Limit